Process for production of N-acyl-.alpha.-amino acids
US4497964A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 1982 |
| Grant date | Feb 5, 1985 |
| Priority date | — |
| Expiry date | Nov 15, 2002 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/845
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A process for the production of an N-acyl-.alpha.-amino acid represented by the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently from each other, represent a hydrogen atom, an alkyl or cycloalkyl group which may be substituted, or an aryl or heteroaromatic group selected from the group consisting of furyl, pyrrolyl, pyridinyl, thienyl and indolyl which may be substituted, which comprises reacting an oxirane represented by the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, an amide compound represented by the general formula EQU R.sup.3 CONHR.sup.4 (III) wherein R.sup.3 and R.sup.4 are as defined above, and carbon monoxide in the presence of hydrogen, a cobalt-containing catalyst, and a promoter composed of a compound containing a metal selected from Groups I, II, III and IV of the periodic table.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.