3-O-Demethyl derivatives of the istamycin B series of compounds
US4499083A · kind A · utility
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5Claims
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Key dates
| Filing date | Sep 3, 1981 |
| Grant date | Feb 12, 1985 |
| Priority date | — |
| Expiry date | Sep 3, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New derivatives of the istamycin B series of compounds are provided, which are 3-O-demethylistamycin B.sub.O, 3-O-demethylistamycin B and 3-O-demethyl-2"-N-formimidoylistamycin B represented generally by Formula I or specifically by Formulae Ia, Ib and Ic, respectively. Compound Ia is useful as an intermediate for the preparation of Compounds Ib and Ic and the latter two compounds exhibit a high antibacterial activity against a wide variety of Gram-positive and Gram-negative bacteria and are useful antibiotics. Also provided are processes for the preparation of the new derivatives starting from istamycin B.sub.O.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.