1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
US4499091A · kind A · utility
21Cited by
3References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1983 |
| Grant date | Feb 12, 1985 |
| Priority date | — |
| Expiry date | Feb 14, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 1-R-1,4-dihydro-4-oxo-6-fluoro-7-(Z.dbd.N--)-quinolinecarboxylic acids and esters thereof, where R is amino, lower-alkylamino, 2-propenylamino or di-lower-alkylamino, R" is hydrogen or lower-alkyl, and Z.dbd.N is a heterocyclic group, useful as antibacterial agents, are prepared by reacting the corresponding 7-chloroquinoline derivatives with the appropriate heterocyclic compound, Z.dbd.NH. A preferred group of compounds are those where Z.dbd.N is 1-piperazinyl or 4-lower-alkyl-1-piperazinyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.