Fused 1,3,5-triazines

US4499269A · kind A · utility

Assignee

• Fisons plc · GB

Inventors

• Colin Bennion · Loughborough, GB
• David Robinson · Shepshed, GB

Key dates

• Filing date: Apr 20, 1983
• Grant date: Feb 12, 1985
• Expiry date: Apr 20, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are described compounds of formula I, ##STR1## in which X is O, S or N--R.sub.7, PA1 each Y, which may be the same or different, is H, OH, alkyl C1-C8, alkoxy C1-C8 or halogen, PA1 n is an integer from 1 to 4 inclusive, PA1 R and R.sub.1, which may be the same or different, are each H; alkanoyl C2-C8 or a group R.sub.4 in which R.sub.4 is alkyl C1-C8 optionally substituted by phenyl; or is cycloalkyl C5 or C6; or is a group of formula XVI, ##STR2## in which W and Z, which may be the same or different, are each H, OH, alkoxy C1-C8, phenyl-alkoxy C7 to C10, alkyl C1-C8, halogen, --NR.sub.2 R.sub.3, --COOR.sub.2, NO.sub.2, alkanoyloxy C2-C8, or --OCH.sub.2 CH.sub.2 NR.sub.2 R.sub.3, and PA2 R.sub.2, R.sub.3 and R.sub.7, which may be the same or different, are each H or alkyl C1-C8, PA2 provided that when X is N--R.sub.7 and R is H, then R.sub.1 is not (a) H when any Y groups are H, alkyl C1-C8, alkoxy C1-C8 or halogen, or (b) unsubstituted phenyl when all Y groups are H, PA2 and pharmaceutically acceptable salts thereof. There is also described the formulation and use of the compounds as pharmaceuticals, and processes for their production.