Derivatives of thienylacetic acid amides and their pharmaceutically acceptable acid salts and a process for the preparation thereof
US4499286A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Nov 22, 1983 |
| Grant date | Feb 12, 1985 |
| Priority date | — |
| Expiry date | Nov 22, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel derivatives of thienylacetic acid amides of the general formula ##STR1## in which the two nitrogens on the cyclohexane ring are transconnected, the basic acetic acid amide radical is in position 2 or 3 of the thiophene nucleus, R is C.sub.1 -C.sub.3 alkyl, R.sub.1 and R.sub.2 are independently C.sub.1 -C.sub.3 -alkyl or represent together with the nitrogen atom to which they are attached a pyrrolidine or piperidine ring and X and Y are independently hydrogen, chlorine or bromine in position 2 to 5 of the thiophene nucleus in dependence on the position of the basic acetic acid amide group, and their pharmaceutically acceptable acid addition salts are .mu.-specific analgetics, which do not cause any physical dependence. Therefore, they are suitable for protracted treatment of pain conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.