Benzoylthio compounds, their preparation and their use as drugs

US4500467A · kind A · utility

Assignee

• BASF SE

Inventors

• Hugo Kubinyi · Bad Dürkheim, DE
• Martin Traut · Heidelberg, DE
• Josef Gries · Monsheim, DE

Key dates

• Filing date: Nov 21, 1983
• Grant date: Feb 19, 1985
• Expiry date: Nov 21, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06165
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Benzoylthio compounds of the formula I ##STR1## where R.sup.1 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.2 and R.sup.4 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.4 -alkylthio, a carboxylic ester group, carboxamido or acylamino or are each an aryl, hetaryl, arylalkylene or hetarylalkylene radical which is unsubstituted or substituted in the aryl moiety by hydroxyl, C.sub.1 -C.sub.4 -alkoxy, arylalkoxy or halogen, R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together may furthermore be a radical --(CH.sub.2).sub.p -- (p=2, 3, 4), --CH.sub.2 --S--CH.sub.2 -- or --CH.sub.2 --C.sub.6 H.sub.4 --CH.sub.2 --(ortho), X is NH or sulfur, m and n are identical or different and are each 0 or 1, and q is 0 or 1 where X is S, and is 0 where X is NH, and their salts with physiologically tolerated bases, their preparation, drugs containing these compounds and the use of these drugs in treating disorders.