Ergoline derivatives
US4500712A · kind A · utility
9Cited by
6References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1982 |
| Grant date | Feb 19, 1985 |
| Priority date | — |
| Expiry date | Nov 1, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D457/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are provided ergoline derivatives of formula ##STR1## wherein R.sub.1 .dbd.H, CH.sub.3 ; R.sub.2 .dbd.H or halogen atom, or CH.sub.3,CN, alkyl- or phenyl-thio; R.sub.3 .dbd.H, OCH.sub.3 ; R.sub.4 .dbd.C.sub.1 -C.sub.4 hydrocarbon group; X.dbd.O, S, NH; A.dbd.CO, SO.sub.2 ; B.dbd.C.sub.1 -C.sub.4 hydrocarbon group, aryl, aralkyl, heterocyclic ring group, alkoxy, aryloxy; n.dbd.0, 1, 2; and pharmaceutically acceptable salts thereof. A process for preparing said compounds is also provided. The compounds show anti-hypertensive activity and are active on the gastroenteric system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.