3-Imino-3H-dibenzo-[c,f]-imidazo-[1,5-a]azepine pharmaceuticals

US4503060A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Gerhard Walther · Bingen, DE
• Claus Schneider · Ingelheim am Rhein, DE
• Karl-Heinz Weber · Gau-Algesheim, DE
• Armin F/u/ gner · Gau-Algesheim, DE

Key dates

• Filing date: Aug 20, 1982
• Grant date: Mar 5, 1985
• Expiry date: Aug 20, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, alkyl of 1 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms; PA1 R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkenyl of 3 to 6 carbon atoms; PA1 R.sub.6 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, phenyl, halo-phenyl, lower alkyl-phenyl, or lower alkoxy-phenyl or ##STR2## R.sub.7 and R.sub.8 are each hydrogen, halogen, alkyl of 1 to 6 carbon atoms or alkoxy or 1 to 6 carbon atoms; PA1 n is an integer from 0 to 4, inclusive; PA1 x is --O--, --S--, or --CH.sub.2 --; and the broken line between the 10 and 13b-positions indicates a single or double bond; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as antiallergics and antithrombotics.