Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions

US4503067A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Fritz Wiedemann · Weinheim, DE
• Wolfgang Kampe
• Max Thiel
• Gisbert Sponer · Hemsbach, DE
• Egon Roesch · Mannheim, DE
• Karl Dietmann

Key dates

• Filing date: Apr 4, 1983
• Grant date: Mar 5, 1985
• Expiry date: Apr 4, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/64
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl; PA0 R.sub.2 is hydrogen, lower alkyl or arylalkyl; PA0 R.sub.3 is hydrogen or lower alkyl; PA0 R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--; PA0 X is a valency bond, --CH.sub.2 --, oxygen or sulfur; PA0 Ar is mono- or bicyclic aryl or pyridyl; PA0 R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl; PA0 R.sub.5 and R.sub.6 together can represent methylenedioxy; and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.