Process for cephalosporanic acid derivatives and intermediate therefor

US4503221A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Hans Fliri · Wien, AT
• Helmut Hamberger · Wien, AT

Key dates

• Filing date: Jun 20, 1983
• Grant date: Mar 5, 1985
• Expiry date: Jun 20, 2003

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The process for preparing cephalosporanic acid derivatives ##STR1## and salts thereof with bases as well as solvates thereof, comprising reacting a compound of the formula II: ##STR2## wherein R.sub.3 represents hydrogen or an amino protecting group and R.sub.2 represents hydrogen, an easily removable ester group or other carboxyl protecting group, with a compound of formula IIIa, ##STR3## wherein R.sub.1 represents hydrogen, an easily removable ester group or other carboxyl protecting group, and R.sub.4 is a 2-benzothiazol group and salts thereof with bases, and if required removing any ester group or protecting group.