Patent · US Expired

Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acetic esters

US4503234A · kind A · utility

8Cited by

7References

5Claims

0Family size

Assignee

LONZA LTD · CH

Inventors

Alfred Huwiler · Visp, CH
Leander Tenud · Visp, CH

Key dates

Filing date	Jul 24, 1981
Grant date	Mar 5, 1985
Priority date	—
Expiry date	Jul 24, 2001

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D277/587
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Process for the production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acetic ester. First 4-chloroacetoacetic ester is oximized and then the resultant chlorohydroxyimino ester, in solution form, reacted with thiourea to produce 2-(2-aminothiazole-4-yl)-2-(syn)-hydroxyimino acetic ester. The latter is methylated with dimethyl sulfate using phase transfer catalysis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.