Process for the preparation of serinol and of serinol derivatives, and products obtained therefrom
US4503252A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 1982 |
| Grant date | Mar 5, 1985 |
| Priority date | — |
| Expiry date | Nov 15, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/088
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the synthesis of serinol and serinol derivatives substituted at the nitrogen atoms by reacting a lower 1,3-dialkoxy-isopropyl halide with ammonia or an amine to form a 1,3-dialkoxy-isopropylamine and then removing the ether groups by heating with a hydrogen halide acid. The method allows the production of serinol and serinol derivatives using inexpensive starting materials in a simple manner and obtaining a high purity product which is free of interfering isomers. Novel compounds obtained by the method which are useful as pharmaceutical intermediates, X-ray contrasting agents and cytostatic or psychopharmacological drugs are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.