Synthetic pyridyl-alanyl decapeptides having antiovulatory activity

US4504414A · kind A · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Karl Folkers · Austin, US
• Cyril Y. Bowers · New Orleans, US
• Teresa M. Kubiak · Richland, US
• Janusz Stepinski · Warszawa, PL

Key dates

• Filing date: Mar 28, 1983
• Grant date: Mar 12, 1985
• Expiry date: Mar 28, 2003

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyridyl-alanyl decapeptides have been effectively synthesized and found to have antiovulatory activity. The exemplary [N-Ac-D-2-Nal.sup.1,pCl-D-Phe.sup.2, D-3-Pal.sup.3,D-Arg.sup.6,D-Ala.sup.10 ]-LHRH has very high potency to inhibit ovulation, both parenterally and orally. Also, this exemplary pyridyl-alanyl-decapeptide showed an unexpected prolonged duration of antiovulatory activity. Such pyridyl-alanyl-decapeptides are useful to control reproduction.