Patent · US Expired

Method of administering calcium channel blocking agents

US4504476A · kind A · utility

2Cited by

1References

8Claims

0Family size

Inventors

Arnold Schwartz · Bridgeport, US
Ingrid L. Grupp · Cincinnati, US
Gunter Grupp · Böhmenkirch, DE
Alain de Pover · Frauenfeld, CH

Key dates

Filing date	Sep 16, 1983
Grant date	Mar 12, 1985
Priority date	—
Expiry date	Sep 16, 2003

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method of potentiating the effect of a dihydropyridine derivative, such as nimodipine or nifedipine, by administering d-cis-diltiazem in an amount sufficient to inhibit calcium influx but insufficient to cause substantial decrease in contractility, and administering a dihydropyridine derivative in a submicromolar amount less than the dosage normally required for pharmacological effectiveness. A calcium channel blocking composition comprises a synergistic combination of d-cis-diltiazem and a dihydropyridine derivative.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.