Purified plasminogen activator, process for its production and thrombolytic composition containing it
US4505893A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 1, 1983 |
| Grant date | Mar 19, 1985 |
| Priority date | — |
| Expiry date | Aug 1, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells, e.g., human embryonic derived cells, human placenta derived cells etc., and having the following properties: PA1 (a) molecular weight measured by gel filtration: 63,000.+-.10,000, PA1 (b) isoelectric point: 7.0-8.5, PA1 (c) affinity to fibrin: present, PA1 (d) affinity to concanavalin A: present, PA1 (e) optimum pH: 7-9.5, and PA1 (f) stability: does not lose activity at 60.degree. C. for 10 hours but loses about 5% of activity at pH 2-3 at 98.degree. C. for a minute; a process for the production of the aforesaid plasminogen activator; and a thrombolytic composition containing the aforesaid plasminogen activator as an active ingredient are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.