Peptide synthesis reagents and method of use
US4507230A · kind A · utility
59Cited by
1References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 12, 1982 |
| Grant date | Mar 26, 1985 |
| Priority date | — |
| Expiry date | May 12, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/12
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded to the organic residue, with a mixture of HF and a base for a time and under conditions effective to produce the release; wherein the amounts of HF and base in the mixture are adjusted so that said release occurs substantially by an S.sub.N 2 mechanism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.