Process for the preparation of .alpha.-aspartyl phenylalanine methyl ester
US4507231A · kind A · utility
3Cited by
4References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 5, 1983 |
| Grant date | Mar 26, 1985 |
| Priority date | — |
| Expiry date | Jul 5, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/801
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of .alpha.-aspartyl phenylalanine methyl ester by reacting phenylalanine methyl ester with the anhydride of N-formyl L-aspartic acid, process wherein the product from said reaction is treated in at least one ion-exchanging resin column and the .beta.-isomer contained in the resulting mixture is isomerized by treatment with acetic anhydride followed by an acid hydrolysis to convert said .beta.-isomer into .alpha.-isomer and ensure the deformylation of said product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.