Process for the preparation of 4-hydroxyquinolines
US4508902A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 16, 1983 |
| Grant date | Apr 2, 1985 |
| Priority date | — |
| Expiry date | Jun 16, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/233
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the preparation of a 4-hydroxyquinoline of the formula: ##STR1## in which R represents a hydrogen atom or one, two or three substituents, which may be the same or different, selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and the trifluoromethyl radical, the substituent(s) being in the 2-, 3-, 5-, 6-, 7- or 8-position, which comprises oxidizing a 1,2,3,4-tetrahydroquinolin-4-one of the general formula: ##STR2## in which R is as hereinbefore defined, in a basic medium, under pressure, by means of excess oxygen or air at a temperature between 80.degree. and 150.degree. C. The 4-hydroxyquinoline products are useful for the preparation of therapeutically useful substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.