Cis-bicyclo[3.3.0]octane derivatives, medicaments containing them and processes for their preparation and use

US4510323A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Horst R. E. Boehlke · Stolberg, DE
• Gerriet K. H. Loschen · Stolberg, DE
• Gudrun E. Michel · Aachen, DE
• Bernd Muller · Flintbek, DE

Key dates

• Filing date: Nov 17, 1982
• Grant date: Apr 9, 1985
• Expiry date: Nov 17, 2002

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Cis-bicyclo[3.3.0]octane derivatives corresponding to the formula ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group or a cation and wherein R.sub.2 represents a cyclohexyl or an adamantyl group. In these compounds the phenyl radical may be arranged with respect to the double bond in the EZ- or in the E-configuration and at the carbon atom bearing the group R.sub.2 the molecule may have the RS- or S-configuration. The compounds are prepared by reacting compounds of the formulae ##STR2## wherein R.sub.1 and R.sub.2 have the same meaning as above and R.sub.6 represents hydrogen or a protecting group. Medicaments containing these compounds act as inhibitors of blood platelet aggregation and (in higher doses) as blood pressure lowering agents.