6-[(4-Substituted piperazin-l-yl)thiocarbonylamino]benzazoles and their use
US4511567A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 16, 1982 |
| Grant date | Apr 16, 1985 |
| Priority date | — |
| Expiry date | Sep 16, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/64
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R.sub.1 represents an optionally 4-substituted piperazino group or a group of the formula R.sub.2 --alk--X.sub.2 --, PA0 R.sub.2 represents optionally esterified carboxy or represents hydroxymethyl, PA0 alk represents lower alkylene or lower alkylidene, PA0 X.sub.1 and X.sub.2, independently of one another, each represents oxygen or sulphur, PA0 Ph represents 1,2-phenylene optionally substituted as well as by the group R.sub.1 --C(.dbd.X.sub.1)--NH--, PA0 X.sub.3 represents oxygen, sulphur or optionally substituted imino, and PA0 R.sub.3 represents optionally fluorine-substituted lower alkyl or cycloalkyl, and their salts. The compounds of the formula I, which have proved to be excellent micro- and macrofilaricides and schistosomacides, are manufactured according to methods known per se.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.