Process for the industrial preparation of collagenous materials from human placental tissues, human collagenous materials obtained and their application as biomaterials
US4511653A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 14, 1983 |
| Grant date | Apr 16, 1985 |
| Priority date | — |
| Expiry date | Oct 14, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/851
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This process of preparation consists in subjecting said placental tissue after pressing, grinding and washing in a neutral and acid medium to a treatment in alkaline medium at a temperature less than or equal to 10.degree. C. and in then subjecting the portions of collagen solubilized during this treatment, as well as the collagen solutions resulting from an eventual subsequent treatment for the solubilization, at least partial, of the insoluble residue, to purification by chromatography on an anion exchange resin, at a temperature less than or equal to 10.degree. C., followed with fractional precipitation of the collagens by salts in acid medium. The human collagenous materials obtained can be used as biomaterials in biotechnology and in pharmacy and are perfectly immunologically innocuous for the human species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.