5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4511724A · kind A · utility
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8Claims
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Key dates
| Filing date | Dec 13, 1982 |
| Grant date | Apr 16, 1985 |
| Priority date | — |
| Expiry date | Dec 13, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted 5-(pyrrol-2-oyl)1,2-dihydropyrrolo[1,2-a]-pyrrole derivatives have been prepared via decarboxylation of the corresponding 1,7-dicarboxylate prepared from condensation of a dialkyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-7-dicarboxylate-7-carboxylic acid with an appropriately substituted 2-pyrroyl chloride, or conversely, an acid chloride of the former bicyclic compounds with a substituted pyrrole. The compounds are analgesic and anti-inflammatory agents of high activities but low ulcerogenic side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.