Process for the preparation of substituted chloroacetanilides
US4511736A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 7, 1983 |
| Grant date | Apr 16, 1985 |
| Priority date | — |
| Expiry date | Jan 7, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N37/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a novel process for preparing chloroacetanilides of the formula ##STR1## wherein: R.sub.1 and R.sub.2 represent independently from each other a hydrogen atom or a C.sub.1-8 alkyl or C.sub.1-8 alkoxy group; and PA1 R.sub.3 stands for a straight chained or branched C.sub.1-8 alkoxy group. Said process is characterized by chloroacetylating a 2,6-dialkylaniline of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, at a temperature of 10.degree. to 120.degree. C., optionally in a solvent medium in the presence of an acid binding agent, then reacting a thus-obtained intermediate with chloromethyl chloroformiate or, alternatively, reacting a compound of the formula (II) first with chloromethyl chloroformiate and subjecting then to chloroacetylation, thereafter reacting a thus-obtained intermediate with an alcohol of the formula EQU R.sub.3 --OH (III), wherein R.sub.3 is as defined above, optionally in a solvent medium in the presence of an acid binding agent, and recovering a product of the formula (I) in a known manner. The process of the invention enables the more simple and economic preparation of the compounds of formula (I) of improved pur…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.