Benzthiazine analogs as antiinflammatory agents
US4512990A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1982 |
| Grant date | Apr 23, 1985 |
| Priority date | — |
| Expiry date | Feb 18, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Z is S; PA0 Y is halo, alkoxy, alkyl, or dialkylamino; PA0 a is 0, 1 or 2; PA0 b is an integer from 2-12 with the proviso that if b is 2 or 3, a cannot be 0, and with the further proviso that if X is OH, b cannot be 2-5 and with the further proviso that if X is --NH.sub.2, b cannot be 2-5; and PA0 X is selected from the group consisting of: --OH, OR.sup.1, --NH.sub.2, --NHR.sup.1, NR1/2, ##STR2## and --NHCONHR.sup.2 in which each R.sup.1 is independently alkyl or cycloalkyl or, in --NR1/2, both R.sup.1 s together are alkylene or form a piperazine ring optionally substituted at the ring N by alkyl or --CH.sub.2 CH.sub.2 OH; and PA1 R.sup.2 is alkyl, cycloalkyl, or optionally substituted phenyl; have antiinflammatory properties and are useful in the treatment of conditions characterized by inflammation and swelling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.