Synthesis of 1-substituted isoquinolines
US4514569A · kind A · utility
11Cited by
3References
16Claims
0Family size
Inventors
Key dates
| Filing date | Jan 28, 1982 |
| Grant date | Apr 30, 1985 |
| Priority date | — |
| Expiry date | Jan 28, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/62
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the synthesis of particular isoquinoline compounds which are useful intermediates in the preparation of members of the family of opium alkaloids, such as morphine and codeine. Steps in the process include the acylation of the isoquinoline nitrogen; reaction of the acylated isoquinoline with a phosphorous compound; and condensation with a benzaldehyde derivative to yield a 1-benzyl isoquinoline.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.