Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
US4515767A · kind A · utility
21Cited by
10References
20Claims
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Key dates
| Filing date | Jun 20, 1983 |
| Grant date | May 7, 1985 |
| Priority date | — |
| Expiry date | Jun 20, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Complexes of radionuclides with a compound of the formula ##STR1## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) phosphonic, sulfonic, methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof. Tc-99m complexes have been found useful for imaging the skeletal structure of animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.