1,5-Diphenyl-2-haloalkylpyrazolin-3-one intermediates

US4515944A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Henning Heinemann · Hannover, DE
• Daniel Jasserand · Paris, FR
• Wolfgang Milkowski
• Dimitri Yavordios · Belleville, FR
• Horst Zeugner

Key dates

• Filing date: Dec 22, 1983
• Grant date: May 7, 1985
• Expiry date: Dec 22, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Intermediates of the isomeric formulae II or III ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxyl, trifluoromethyl or lower alkanoyloxy group, PA1 R.sub.2 is a hydrogen or halogen atom, or a lower alkyl or lower alkoxy group, or PA1 R.sub.1 and R.sub.2 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy group, PA1 R.sub.3 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxy, trifluoromethyl or lower alkanoyloxy group, PA1 R.sub.4 is a hydrogen or halogen atom, or a lower alkyl or lower alkoxy group, or PA1 R.sub.3 and R.sub.4 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy group, Z is an alkylene group with 2 to 6 carbon atoms, Z' is an alkylene group with 2 to 4 carbon atoms, Y is a halogen atom, and Y' is a halogen atom, and acid addition salts thereof, are useful to prepare antiallergic 2-piperazinoalkyl-1, 5-diphenylpyrazolin-3-ones.