Mammalian PGRF

US4517181A · kind A · utility

Assignee

• Salk Institute for Biological Studies · US

Inventors

• Nicholas C. Ling · San Diego, US
• Frederick S. Esch · Oceanside, US
• Peter Bohlen · Uster, CH
• Paul Brazeau · Mount Royal, CA
• Roger C. L. Guillemin · Village of La Jolla, US

Key dates

• Filing date: Sep 15, 1982
• Grant date: May 14, 1985
• Expiry date: Sep 15, 2002

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

PGRF has been synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: ##STR1## wherein R is OH or NH.sub.2, R.sub.34 is Ser or Ala, R.sub.38 is Arg or Ser, R.sub.40 is Ala or Arg and R.sub.41 is Arg, Arg-Ala, Arg-Ala-Arg, Arg-Ala-Arg-Leu or des-R.sub.41. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically.