2,6,7,8-Substituted quinazolines, process for production thereof, and use thereof
US4517189A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1983 |
| Grant date | May 14, 1985 |
| Priority date | — |
| Expiry date | Aug 2, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A 2,6,7,8-substituted quinazoline represented by the following formula ##STR1## wherein R.sub.1 and R.sub.3 each represent a lower alkyl group, R.sub.2 represents a lower alkoxy-carbonyl group, and A represents a lower alkyl group, or a phenyl or benzyl group which is unsubstituted or substituted by a substituent selected from the class consisting of halogen atoms, a trifluoromethyl group and lower alkyl groups, or its acid addition salt. The said compound can be prepared by reacting a compound represented by the following formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and A are as defined, with ammonia. A pharmaceutical composition comprising the said compound as an active ingredient is useful for the treatment of disorders of the circulatory system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.