Process for the production of heparin-containing particulate products

US4518771A · kind A · utility

Assignee

• Richter Gedeon Vegyeszeti Gyar RT · HU

Inventors

• Istvan Takacs · Budapest, HU
• Gyorgy Kerey · Budapest, HU
• Janos Illes · Budapest, HU
• Peter Rudolf · Ludwigshafen, DE
• Pal Gere · Budapest, HU
• Laszlo Czebe · Budapest, HU
• Erzsebet Neszmelyi · Budapest, HU

Key dates

• Filing date: Dec 23, 1980
• Grant date: May 21, 1985
• Expiry date: Dec 23, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0075
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A heparin-enriched material capable of long-term storage and particularly adapted for use as a raw material in processes for the extraction of heparin is produced by storing the animal organ material for a period of 0.5 to 15 hours (preferably 4 to 6 hours) at a temperature of 10.degree. to 50.degree. C. (preferably 30.degree. to 50.degree. C.), then injecting steam to effect a heat treatment at a temperature between 75.degree. and 100.degree. C. The heat treatment precipitates heparin-containing aggregate which is filtered from the aqueous phase and dried to a dry substance content of 90 to 95%.