Polymeric compounds with sustained anti-tumor activity and a method for the preparation thereof
US4520162A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1984 |
| Grant date | May 28, 1985 |
| Priority date | — |
| Expiry date | Sep 17, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The novel polymeric compound proposed in the invention has a backbone structure formed of a copolymeric moiety of maleic anhydride and divinyl ether and pendant groups thereon derived from an anthracycline-type anti-tumor agent, e.g. adriamycin and daunomycin, or 1-.beta.-D-arabinofuranosylcytosine bonded to the maleic anhydride units in the backbone structure by forming amide linkages, the remaining anhydride units in the backbone structure being hydrolyzed into free acid form or a salt thereof. Both in vitro and in vivo tests indicate that the anti-tumor active pendant groups in the polymeric compound can be released sustainedly to exhibit the anti-tumor activity with greatly decreased side effects unavoidable when the above mentioned anti-tumor agents as such are administrated to a patient in a relatively large dose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.