Antitumor agent
US4521406A · kind A · utility
4Cited by
0References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 20, 1981 |
| Grant date | Jun 4, 1985 |
| Priority date | — |
| Expiry date | May 20, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y305/04001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antitumor agent comprising a combination of 5-fluorocytosine and cytosinedeaminase has been developed. As to the practical administration procedure of the agent, it is preferable to carry out in such a manner that 5-fluorocytosine is first administered in any portion of the body, and cytosinedeaminase is then administered into the topically suffered portion. The administered 5-fluorocytosine is transferred into the suffered portion, and the 5-fluorocytosine is affected with the action of cytosinedeaminase to convert the former compound into 5-fluorouracil, resulting in that the necrosis of the tumor tissue is caused.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.