Protection against dental caries
US4521513A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 3, 1983 |
| Grant date | Jun 4, 1985 |
| Priority date | — |
| Expiry date | Feb 3, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antigenic protein, termed antigen C, present on the cell walls and in cultures of Streptococeus mutans, especially genetic group I (serotypes c, e and f) is separated from other antigenic proteins, notably those which react heart tissue, to give an antigen preparation which may be used as a vaccine or to raise antibodies for use in protecting against dental caries. Antigen C is destroyed or extracted from the cell walls by treatment with boiling aqueous sodium dodecyl sulphate (10 gm per liter) for 10 minutes. It has a molecular weight of 70,000.+-.5,000 and an isoelectric point of 4.45.+-.0.24. It is destroyed by proteolytic enzyme and does not cross react with heart tissue. The antigen also occurs in the culture filtrate and/or cell extract and may readily be separated from these sources by affinity chromatography on immobilised antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.