1'-Substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-triones
US4523021A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 1984 |
| Grant date | Jun 11, 1985 |
| Priority date | — |
| Expiry date | Aug 7, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a pharmaceutical composition comprising an aldose reductase inhibitory 1'substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-trione of the formula: ##STR1## wherein Ra is (2-7C)alkyl or (3-7C)alkenyl, naphthylmethyl or cinnamyl optionally bearing one or two halogeno nuclear substituents, or Ra is benzyl optionally bearing one or two substituents and benzene ring A optionally bears one or two substituents, trifluoromethyl and nitro; or a salt thereof with a base affording a pharmaceutically acceptable cation; or a non-toxic, biodegradable precursor thereof; together with a pharmaceutically acceptable diluent or carrier. The invention also provides novel compounds of formula I and processes for their manufacture. The compositions are of application in the treatment or prophylaxis of the side effects of diabetes or galactosemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.