Preparation of isochromane derivatives

US4523023A · kind A · utility

Assignee

• Haarmann & Reimer Corporation · DE

Inventors

• Horst Finkelmeier · Holzminden, DE
• Rudolf Hopp · Holzminden, DE

Key dates

• Filing date: Jan 31, 1984
• Grant date: Jun 11, 1985
• Expiry date: Jan 31, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/94
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of an isochromane of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and denote hydrogen, lower alkyl or lower alkoxy, or together form a cyclopentane or cyclohexane ring which is optionally substituted by lower alkyl and PA1 R.sup.3 denotes hydrogen or lower alkyl, comprising reacting an alcohol of the formula ##STR2## with formaldehyde and a carboxylic acid anhydride of the formula ##STR3## or with a methylene diester of the formula ##STR4## in which R.sup.4 represents a lower alkyl radical, in the presence of an acid catalyst. The products are known, having a musk-like odor.