Pyrimidone derivatives

US4524071A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Barry J. Price · London, GB
• John W. Clitherow · Sawbridgeworth, GB
• John Bradshaw · Solon, US
• Michael Martin-Smith · Hertford, GB
• Duncan B. Judd · Ware, GB
• Roger Hayes · Digswell, GB

Key dates

• Filing date: Jul 17, 1979
• Grant date: Jun 18, 1985
• Expiry date: Jul 17, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I) ##STR1## in which R.sub.1 and R.sub.2 each may represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, or alkyl, substituted by hydroxy, C.sub.1-3 alkoxy, amino, C.sub.1-3 alkylamino or di-C.sub.1-3 alkylamino or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form an alicyclic heterocyclic ring which may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom are described. PA1 Alk is a straight lower alkylene chain, PA1 Q is a furan or thiophen ring, the furan ring optionally bearing a further substituent R.sub.5 adjacent to the group R.sub.1 R.sub.2 NAlk-- or Q represents a benzene ring. PA1 R.sub.5 represents halogen or C.sub.1-3 alkyl which may be substituted by a hydroxy or C.sub.1-3 alkoxy group; PA1 X represents --CH.sub.2 --, --O-- or --S--; PA1 n represents zero or 1; PA1 m represents 2, 3 or 4; PA1 Y represents .dbd.O or .dbd.S; PA1 R.sub.3 represents hydrogen in which case R.sub.4 represents methyl or R.sub.3 represents --(CH.sub.2).sub.p V(CH.sub.2).sub.q Ar, phenyl, or alkyl in which case R.sub.4 represents hydrogen; PA1 V…