Conjugates of anticoagulant and protein
US4526714A · kind A · utility
74Cited by
7References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1982 |
| Grant date | Jul 2, 1985 |
| Priority date | — |
| Expiry date | Dec 13, 2002 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L33/0011
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.