Dentifrice containing dual sources of fluoride
US4528181A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 1, 1984 |
| Grant date | Jul 9, 1985 |
| Priority date | — |
| Expiry date | Feb 1, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/412
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Dentifrice containing a liquid vehicle containing water, a gelling agent, a dual source of at least about 500 ppm of fluorine comprising sodium fluoride and sodium monofluorophosphate, a precipitated, amorphous silica gel having an average particle size of 1 to 30 microns and PA0 (a) a surface area of 1 to 600 m.sup.2 /g, PA0 (b) a pore volume of 0.05 to 0.5 cm.sup.3 /g, PA0 (c) a product of surface area (in m.sup.2 /g).times.pore volume (in cm.sup.3 /g) less than or equal to 240, PA0 (d) a calculated pore diameter of 1.5 to 2.5 nm, and PA0 (e) a water content of less than 25% by weight, a source of calcium corresponding to up to about 0.004% by weight (40 ppm) of calcium ion and about 0.25%-5% by weight of an alkali metal phytate. The alkali metal phytate improves retention of total soluble fluorine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.