Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone
US4528371A · kind A · utility
1Cited by
3References
8Claims
0Family size
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Key dates
| Filing date | Jun 14, 1983 |
| Grant date | Jul 9, 1985 |
| Priority date | — |
| Expiry date | Jun 14, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C59/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.