Isolation of chemically unstable antibiotics from fermentation solutions

US4529545A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerhard Huber · Frankenhofen, DE
• Peter Schindler · Rodgau, DE

Key dates

• Filing date: Nov 19, 1982
• Grant date: Jul 16, 1985
• Expiry date: Nov 19, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P17/184
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for isolating a chemically unstable carbapenem antibiotic from a fermentation solution by adsorbing the antibiotic on an ion exchanger resin at the maximum of product formation, thus converting it to a stabilized form, and then separating the resin from the fermentation solution.