1H,3H-pyrrolo[1,2-c]thiazole derivatives having anti-allergic and anti-inflammatory activity

US4529728A · kind A · utility

Assignee

• Rhone-Poulenc Sante · FR

Inventors

• Jean-Louis Fabre · Paris, FR
• Daniel Farge · Thiais, FR
• Claude James · Paris, FR
• Daniel Lave · Paris, FR

Key dates

• Filing date: Jan 11, 1984
• Grant date: Jul 16, 1985
• Expiry date: Jan 11, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 =H or alkyl and PA0 (a) R=CN or alkylcarbonyl, or PA0 (b) R=CON(R.sub.3)R.sub.4, in which R.sub.3 =H and R.sub.4 =NH.sub.2, alkylamino, dialkylamino, phenylamino or diphenylamino; or R.sub.3 and R.sub.4 =H, alkyl (1 to 5 C) or substituted phenyl; or R.sub.3 =H and R.sub.4 =pyridyl or alkyl (1 to 5 C) substituted by COOH, NH.sub.2, alkylamino, dialkylamino, morpholino, piperidino, pyrrolidin-1-yl, piperazin-1-yl (optionally substituted by alkyl, pyridyl or optionally substituted phenyl or benzyl), optionally substituted phenyl, pyridyl or imidazolyl; or R.sub.3 and R.sub.4 form an imidazolyl radical or a 5-membered or 6-membered heterocycle which can contain an oxygen, sulphur or nitrogen atom and which is optionally substituted by alkyl, alkoxycarbonyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, pyridyl, pyrimidinyl, pyrazinyl, optionally substituted phenyl or optionally substituted benzyl; or PA0 (c) R=--C(.dbd.NOH)NH.sub.2 or --C[.dbd.NN(R'R")NH.sub.2 ], in which R' and R"=alkyl, the said alkyl radicals and alkyl portions being straight-chain or branched-chain and, unless mentioned otherwise, co…