Nonthrombogenic articles having enhanced albumin affinity
US4530974A · kind A · utility
24Cited by
19References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 13, 1982 |
| Grant date | Jul 23, 1985 |
| Priority date | — |
| Expiry date | Jul 13, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J7/12
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
Articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extensions of 14 to 20 carbon units. When exposed to blood the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.