Method of preparing giant size liposomes
US4532089A · kind A · utility
58Cited by
3References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 14, 1984 |
| Grant date | Jul 30, 1985 |
| Priority date | — |
| Expiry date | Jan 14, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Large size liposomes are produced from small unilamellar vesicles by incorporating a polar compound in an aqueous dispersion of the vesicles, subjecting the dispersion to repeated freeze-thaw cycles, and thereafter dialyzing the vesicles against a hypoosmotic medium. The freeze-thaw cycles aggregate the vesicles and increase their internal concentration of polar compound. During dialysis the vesicles imbibe water, rupture, and form enlarged liposomes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.