Amidine compounds and anticomplement agent comprising same
US4532255A · kind A · utility
26Cited by
2References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 20, 1984 |
| Grant date | Jul 30, 1985 |
| Priority date | — |
| Expiry date | Jan 20, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C279/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-C1 (C1r, C1s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula ##STR2## with 6-amidino-2-naphthol and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.