2-Acylaminomethyl-1,4-benzodiazepine compounds and analgesic use

US4533662A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Horst Zeugner
• Dietmar Roemer · Pfullendorf, DE
• Hans Liepmann · Hannover, DE
• Wolfgang Milkowski

Key dates

• Filing date: Dec 14, 1981
• Grant date: Aug 6, 1985
• Expiry date: Dec 14, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D243/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4-benzo diazepine compounds of the following Formula I ##STR1## which have valuable pharmacological properties are provided. In said Formula I the acyl group --CO--R.sub.3 represents a benzoyl group or a phenyl alkanoyl group which may be unsubstituted or mono- or di-substituted in the phenyl ring. The substituent R.sub.1 in said compounds indicates lower alkyl, lower alkenyl, or cyclopropyl methyl, and the substituent R.sub.2 indicates hydrogen, lower alkyl, or lower alkenyl, while the substituent R.sub.6 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifluoro methyl, cyano, amino, mono- or di-lower alkyl amino, lower mono-alkanoyl amino, lower N-alkyl-N-alkanoyl amino, or lower alkanoyloxy, and the substituent R.sub.7 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, whereby R.sub.6 and R.sub.7, when attached to adjacent carbon atoms, may form together the methylene dioxy or the ethylene dioxy group. The substituents R.sub.8 and R.sub.9 designate the same substituents as indicated for the substituents R.sub.6 and R.sub.7. The compounds of Formula I…