Polyene compounds useful in the treatment of psoriasis and allergic responses
US4534979A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 1984 |
| Grant date | Aug 13, 1985 |
| Priority date | — |
| Expiry date | Nov 2, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyene compounds represented by the general formulae ##STR1## in which: R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; PA0 R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; PA0 R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl, aryloxy, aralkyloxy or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.