11.beta.-aryl estradienes, processes for their production and pharmaceutical preparations containing them

US4536401A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Guenter Neef · Berlin, DE
• Gerhard Sauer · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Helmut Hofmeister · Berlin, DE
• Ralph Rohde · Berlin, DE
• Klaus Annen · Berlin, DE
• Henry Laurent
• Sybille Beier · Berlin, DE
• Wolfgang Losert
• Walter Elger · Berlin, DE
• David Henderson · Berlin, DE

Key dates

• Filing date: Feb 21, 1984
• Grant date: Aug 20, 1985
• Expiry date: Feb 21, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/001
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## wherein R.sub.1 is ##STR2## wherein R.sup.I and R.sup.II each independently is alkyl of 1-4 carbon atoms, or R.sup.I and R.sup.II together with the connecting N-atom form a 5- or 6-membered heterocyclic ring whose remaining atoms are all C-atoms, or which also includes and additional N-atom, an additional O or S atom or a combination thereof; ##STR3## wherein R.sup.I and R.sup.II are as defined above; --SR.sup.III, wherein R.sup.III is methyl, ethyl or phenyl; or PA1 --OR.sup.IV, wherein R.sup.IV is methyl, ethyl, propyl, methoxymethyl, allyl, or .beta.-dimethylaminoethyl; R.sub.2 is hydrogen, methyl, or ethyl; ##STR4## wherein the wavy lines mean that the substituent is in the .alpha.- or .beta.-position, and ##STR5## M is Na, K or Li; and R.sup.V, R.sup.VI, R.sup.VII and R.sup.VIII each independently is alkyl of 1-4 carbon atoms, have valuable pharmacological properties, e.g., a combination of antiprogestational and antimineralocorticordal effects.