Naphthoxyalkylamines and related compounds as antiinflammatory agents
US4536503A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 9, 1984 |
| Grant date | Aug 20, 1985 |
| Priority date | — |
| Expiry date | Jan 9, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C275/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein; Y is halo, alkoxy, alkyl, or dialkylamino; PA0 a is 0, 1 or 2; PA0 b is an integer from 2-12 with the proviso that if b is 2 or 3 a cannot be 0; and PA0 X is selected from the group consisting of: --OH, OR.sup.1, --NH.sub.2, --NHR.sup.1, NR.sub.2.sup.1, ##STR2## and --NHCONHR.sup.2 in which each R.sup.1 is independently alkyl or cycloalkyl or in --NR.sub.2.sup.1, both R.sup.1 together are alkylene or form a piperazine ring optionally substituted at the ring N by alkyl or --CH.sub.2 CH.sub.2 OH; and PA1 R.sup.2 is alkyl, cycloalkyl, or optionally substituted phenyl; PA0 have antiinflammatory properties and are useful in the treatment of conditions characterized by inflammation and swelling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.