Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4537776A · kind A · utility
165Cited by
14References
22Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 21, 1983 |
| Grant date | Aug 27, 1985 |
| Priority date | — |
| Expiry date | Jun 21, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Topical pharmaceutical compositions comprising a pharmaceutically-active agent and a novel, penetration-enhancing vehicle or carrier are disclosed. The vehicle or carrier comprises a binary combination of N-(2-Hydroxyethyl) pyrrolidone and a "cell-envelope disordering compound". The compositions provide marked transepidermal and percutaneous delivery of the active selected. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.