Lyophilized cyclophosphamide
US4537883A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1984 |
| Grant date | Aug 27, 1985 |
| Priority date | — |
| Expiry date | Mar 13, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/675
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized cyclophosphamide solid composition demonstrates improved stability, solubility characteristics and enhanced appearance compared with currently available dry powder pre-mix compositions of cyclophosphamide. The lyophilized solid composition contains about 20 parts by weight of cyclophosphamide, about 11/4-2 parts by weight of water and from about 10-85 parts by weight of excipient which is comprised mainly of mannitol. Processes for making the composition are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.